Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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5,146 – 5,160 of 60,541 results

5,146

Medchemexpress LLC N1,N5-Bis-boc-spermidine | 68076-39-1 | 99.8% | 345.48 | 100 MG

N1,N5-Bis-Boc-spermidine is a linker that features an amino group along with two Boc-protected amino groups. This amino group is reactive with various substances such as carboxylic acids, activated NHS esters, and carbonyls like ketone and aldehyde. The Boc group can be deprotected when exposed to mild acidic conditions, resulting in the formation of a free amine.

Linker containing an amino group with two Boc-protected amino groups.
Amino group is reactive with carboxylic acids, activated NHS esters, and carbonyls (ketone, aldehyde).
Boc group can be deprotected under mild acidic conditions to form the free amine.
Soluble in DMSO at a concentration of at least 100 mg/mL (289.45 mM).
Store at 4°C, protected from light.
When in solvent, store at -80°C for 6 months or -20°C for 1 month (protect from light).
Purity is 99.78%.

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5,147

Apexbio Technology LLC Sivelestat sodium tetrahydrate, 10mg CAS# 201677-61-4

Sivelestat sodium tetrahydrate is a potent competitive inhibitor of human neutrophil elastase (HNE) with IC50 of 44 nM and Ki of 0.2 M. It is also known as ONO5046, LY544349 and EI546. It can also inhibit leukocyte elastase in rabbit, rat, hamster and mouse. Other sizes are also available. Please inqury us for quote.

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5,148

Cayman Chemical MPP-PICA, Purity: ≥98%, 1 mg

An analytical reference standard that is structurally similar to known synthetic cannabinoids; intended for research and forensic applications

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5,149

AdipoGen 7-Amino-NBD

Chemical. CAS 10199-91-4. Formula C6H4N4O3. MW 180.12. Synthetic. Fluorogenic amine. Building block and reagent for synthesis of fluorescent probes. Used for the preparation of fluorogenic substrates, chemosensors and probes, in which NBD-amine is the high fluoresence component after release. Shows constant fluorescence intensity from pH2-9. Spectral data Ex=472nm, Em=555nm TRIS buffer, pH7.8

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5,150

TARGETMOL CHEMICALS INC PNZ5 5MG

Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. PNZ5 is a potent and isoxazole-based pan-BET inhibitor with high selectivity and potency similar to the well-established (+)-JQ1 with a KD of 5.43 nM for BRD4(1). purity: 99%

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5,151

Cayman Chemical TA-02, Purity: ≥98%, CAS: 1784751-19-4, 10 mg

An inducer of cardiomyocyte differentiation; increases expression of the cardiomyocyte marker NKX2-5 by >2-fold and decreases expression of mesoderm markers and the pre-cardiac marker Isl-1 in HES-3 NKX2-5eGFP/w cells at 5 μM; inhibits CK1ε and CK1D and reduces expression of Wnt/β-catenin signaling pathway members

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5,152

Cayman Chemical RAF709, Purity: ≥98%, CAS: 1628838-42-5, 1 mg

A potent inhibitor of B-RAF and C-RAF (IC50s = 0.4 and 0.5 nM, respectively); selective for RAF kinases exhibiting >99% inhibition of only B-RAF, B-RAFV600E, and C-RAF in a panel of 456 kinases; DDR1, DDR2, FRK, and PDGFRβ are also inhibited by >80% at a concentration of 1 μM; inhibits phosphorylation of MEK and ERK (EC50s = 0.02 and 0.1 μM, respectively) with minimal paradoxical activation, stabilizes BRAF-CRAF dimers (EC50 = 0.8 μM), and reduces proliferation of Calu-6 RAS mutant cells (EC50 = 0.95 μM); reduces ERK phosphorylation and decreases tumor volume without affecting total body weight in a Calu-6 mouse NSCLC xenograft model when administered at doses ranging from 10-200 mg/kg

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5,153

Medchemexpress LLC KIR2DL1 Human Biot 20ug | 20ug

KIR2DL1 found on NK cells serves as a receptor for specific HLA-C alleles inhibiting NK cell activity to prevent cell lysis This regulatory function involves interactions with ARRB2 and additionally engages PTPN6 and PTPN11 The interaction s enhancement by ARRB2 underscores KIR2DL1 s role in complex signaling networks that modulate NK cell function KIR2DL1 Protein Human (Biotinylated HEK293 His-Avi) is the recombinant human-derived KIR2DL1 protein expressed by HEK293 with C-Avi C-His labeled tag

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5,154

Medchemexpress LLC Amilo-5MER TFA (5-MP TFA) | 99.6% | 576.66 (free base) | 5 MG

Amilo-5MER TFA (5-MP) is an orally active and selective Serum Amyloid A (SAA) inhibitor. It specifically inhibits the release of pro-inflammatory cytokines IL-6 and IL-1β from SAA-activated cells. This compound has shown the ability to reduce chronic inflammation and alleviate symptoms associated with diseases like rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS). It is considered promising for research in autoimmune and chronic inflammatory diseases.

Orally active and selective Serum Amyloid A (SAA) inhibitor.
Specifically inhibits the release of pro-inflammatory cytokines IL-6 and IL-1β from SAA-activated cells.
Reduces chronic inflammation.
Relieves symptoms of diseases such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), and multiple sclerosis (MS).
Promising for research of autoimmune diseases and chronic inflammatory diseases.

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5,155

eMolecules 1416881-52-1 | 4CzIPN | ChemScene788.914 | C56H32N6 | 98.000 | N#Cc1c(c(C#N)c(c(c1-n1c2ccccc2c2ccccc12)-n1c2ccccc2c2ccccc12)-n1c2ccccc2c2ccccc12)-n1c2ccccc2c2ccccc12 | 1g | 572189573

4CzIPN | ChemScene | 1416881-52-1788.914 | C56H32N6 | 98.000 | N#Cc1c(c(C#N)c(c(c1-n1c2ccccc2c2ccccc12)-n1c2ccccc2c2ccccc12)-n1c2ccccc2c2ccccc12)-n1c2ccccc2c2ccccc12 | 1g | 572189573

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5,156

eMolecules 79756-69-7 | Medchem Express | TPI-1 | 5mg | 446255535 | HY-100463 | MFCD00448731 | 253.08 | C12H6Cl2O2

Medchem Express | TPI-1 | 5mg | 446255535 | HY-100463 | 79756-69-7 | MFCD00448731 | 253.080 | C12H6Cl2O2

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5,157

Cayman Chemical Didecanoin, Purity: ≥98%, CAS: 53988-07-1, 250 mg

A diacylglycerol

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5,158

Medchemexpress LLC [D-Ala2]leucine-enkephalin | 64963-01-5 | 98.6% | 569.65 | 1 ML

[D-Ala2]leucine-enkephalin is a delta opioid agonist and a degradation-resistant, long-acting Leu-enkephalin analog. It is used to study the signaling pathway of delta opioid receptors. It is widely distributed in the human body and possesses vital physiological functions.

Activates dormant brain cells and facilitates recovery of sequelae from brain damage.
Enhances immune system activity, including T lymphocytes, NK cells, and macrophages.
Exerts antiviral effects and promotes gamma-interferon secretion.
Participates in immune regulation by stimulating endocrine cell secretion, influencing gene regulation and DNA expression.

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5,159

Cayman Chemical BAY 12-17389, Purity: ≥95%, CAS: 1554458-53-5, 1 mg

An Mps1 inhibitor (IC50 = 0.63 nM); selective for Mps1 over a panel of kinases at 10 nM; promotes mitosis progression in metaphase-arrested HeLa cells (IC50 = 11 nM); enhances paclitaxel-induced inhibition of tumor growth in a SUM149 TNBC mouse xenograft model

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5,160

Medchemexpress LLC [D-Leu-4]-OB3 | 289056-32-2 | 98.9% | 734.82 | 5 MG

[D-Leu-4]-OB3 is an agent that inhibits the expression of pro-inflammatory, proliferative, and metastatic genes, as well as PD-L1 expression. It also stimulates the expression of pro-apoptotic genes.

Inhibits pro-inflammatory genes
Inhibits proliferative genes
Inhibits metastatic genes
Inhibits PD-L1 expression
Stimulates pro-apoptotic genes

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Bioactive Small Molecules

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Medchemexpress LLC N1,N5-Bis-boc-spermidine | 68076-39-1 | 99.8% | 345.48 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC KIR2DL1 Human Biot 20ug | 20ug Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Amilo-5MER TFA (5-MP TFA) | 99.6% | 576.66 (free base) | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC [D-Ala2]leucine-enkephalin | 64963-01-5 | 98.6% | 569.65 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC [D-Leu-4]-OB3 | 289056-32-2 | 98.9% | 734.82 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC N1,N5-Bis-boc-spermidine | 68076-39-1 | 99.8% | 345.48 | 100 MG

Medchemexpress LLC KIR2DL1 Human Biot 20ug | 20ug

Medchemexpress LLC Amilo-5MER TFA (5-MP TFA) | 99.6% | 576.66 (free base) | 5 MG

Medchemexpress LLC [D-Ala2]leucine-enkephalin | 64963-01-5 | 98.6% | 569.65 | 1 ML

Medchemexpress LLC [D-Leu-4]-OB3 | 289056-32-2 | 98.9% | 734.82 | 5 MG