Bioactive Small Molecules
Cayman Chemical CamelInIn A 5mg
A flavonoid with diverse biological activities; inhibits ACE by 30.16% at 500 UG/ml; induces cell cycle arrest at the G1 phase and apoptosis in HepG2 and MCF-7 cells at 200 µM; reduces hepatocyte apoptosis, as well as hepatic TNF-α, IL-6, IL-1β, and MDA levels, in a mouse model of carbon tetrachloride-induced liver injury at 30 mg/kg
Cayman Chemical ANTIBODY ND-646 5mg
An ACC inhibitor (IC50s = 3.5 and 4.1 nM for human ACC1 and ACC2, respectively); inhibits production of palmitate and total fatty acid content in A549 cells at 500 nM; induces apoptosis and ER stress in A549 cells at 500 nM; inhibits fatty acid synthesis and reduces tumor growth in an A549 mouse xenograft model at 25 mg/kg twice per day
Cayman Chemical GnglIosIde GD1bbovInso 5mg
A mixture of ganglioside GD1b molecular species isolated from bovine brain with primarily C18:0 fatty acyl chain lengths; a component of plasma membranes; packs densely with cholesterol to form lipid microdomains that modulate both intra- and intercellular signaling events; the concentration of ganglioside GD1b in human brain increases with age
Cayman Chemical V-0219hydrochlorIde 5mg
A positive allosteric modulator of GLP-1R; selective for GLP-1R over a panel of 54 other receptors, ion channels, and transporters at 10 µM; potentiates GLP-1-induced cAMP accumulation in HEK293 cells expressing human GLP-1R at 0.001-1 nM; potentiates GLP-1-induced insulin secretion in INS-1E rat insulinoma cells; improves glucose tolerance in wild-type, but not Glp1r knockout, mice at 0.1 mg/kg; enhances an exendin-4-induced reduction in food intake in rats at 0.001 mg/kg
Cayman Chemical PUMA BH3humntrIfluoroac 5mg
A peptide activator of Bak; binds to Bak (Kds = 290 and 26 nM in HEPES and CHAPS buffer, respectively) and induces Bak homo-oligomerization and Bak-mediated membrane permeabilization
Cayman Chemical ANTIBODY YW1159 10mg
An inhibitor of Wnt signaling (IC50 = 1.2 nM); not cytotoxic to HEK293 cells following incubations of up to 24 hours but cell viability is decreased in a concentration-dependent manner after 72 hours
Apexbio Technology LLC Metronidazole, 10g Cas# 443-48-1
Metronidazole 50mg Metronidazole There are other sizes available. Please inqury us for quote.
Cayman Chemical ANTIBODY-mT5-14 5mg
A derivative of remdesivir with antiviral activity; increases the viability of Vero E6 cells infected with SARS-CoV-2 (EC50 = 0.4 µM), as well as Vero E6 cells infected with the Alpha, Beta, Gamma, or Delta SARS-CoV-2 variants (EC50s = 2.5, 15.9, 1.7, and 5.6 µM, respectively); exhibits increased plasma and lung concentrations compared with remdesivir in hamsters at 10 mg/kg
Enzo Life Sciences Leukotriene B4 (1mg). CAS: 71160-24-2
Activator of PPARα. Stimulates leukocyte functions including chemokinesis, chemotaxis, lysosomal enzyme release, adhesion, stimulation of ion fluxes, superoxyde anion production and C3b receptor expression. Induces vascular permeability, NK cell activity, and broncho-constriction. UVmax: 270 nm (50,000). Alternative name: LTB4, 5,12-Dihydroxy-[S-[R*,S*-(E,Z,Z,E)]]-6,8,10,14-eicosatetraenoic acid. Formulation: Oil dissolved in ethanol. Purity: ≥97% (HPLC). Long Term Storage: -80°C.
Selleck Chemical LLC Serabelisib (TAK-117) 5mg 1268454-23-4 INK-1117, MLN-1117
Serabelisib (TAK-117, INK-1117, MLN-1117) is a potent and selective oral PI3K? isoform inhibitor (IC50 of 21 nmol/L against PI3K?) that has demonstrated > 100-fold selectivity relative to other class I PI3K family members (PI3K?/?/?) and mTOR, and a high degree of selectivity against many other kinase. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Cayman Chemical InsulIn SensItIzer C59 25mg
A potentiator of insulin-induced Glut4 plasma membrane translocation; enhances insulin-stimulated increases in plasma membrane levels of Glut4 in a reporter assay using C2C12 cells at 10 µM; decreases fasting blood levels of glucose, fasting plasma levels of insulin, and body weight in mice fed a high-fat diet at 10 mg/kg per day; potentiates insulin-induced increases in the plasma membrane translocation of Glut4 in the forelimbs, hind limbs, brown adipose tissues, and heart but not brain or liver in mice in a model of diet-induced obesity
Enzo Life Sciences Vincristine. sulfate (5 mg). CAS: 2068-78-2
Plant alkaloid that arrests the cell cycle in G2/M phase by blocking mitotic spindle formation. Depolymerizes microtubules and blocks binding of tubulin to microtubule proteins. Causes aberrant tubulin polymerization. Induces apoptosis. Triggers Raf-1 activation, phosphorylation of Bcl-2 family proteins and induction of p53 expression. Cancer chemotherapeutic agent. Posttranscriptionally downregulates HIF-1α expression. Alternative name: VCR . sulfate, Leukocristine . sulfate. Purity: ≥98% TLC. Solubility: Soluble in water (25mg/ml) or methanol. Long Term Storage: -20°C.
Enzo Life Sciences Ac-LEHD-AMC (5mg). CAS: 292633-16-0
Caspase-9 substrate. Fluorogenic substrate for caspase-9 and related cysteine proteases. The LEHD sequence is derived from combinatorial experiments. Ex.:340-360nm, Em.:440-460nm. Alternative name: Caspase 9 substrate (fluorogenic). Formula: C33H41N7O11. MW: 711.7. Purity: ≥98% HPLC. Appearance: White to off-white powder. Peptide content: 75-95%. Solubility: Soluble in water, DMSO or phosphate buffer, pH 7.5. Long Term Storage: -20°C. Handling: Keep cool and dry.
Cayman Chemical ANTIBODY LuzIndole 50mg
A melatonin receptor antagonist that preferentially targets MT1B over MT1A (Ki values = 10-27 and 158-513 nM, respectively); used both in vitro and in vivo to evaluate the roles of melatonin receptor signaling in diverse pathways